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Cell death and disease....right signaling is the key

Cell death Fig.png

References / Further Reading

Chanchal Chauhan, Andreas Kraemer, Stefan Knapp, Mark Windheim, Alexey Kotlyarov, Manoj B. Menon*, Matthias Gaestel*(2023). 5-iodotubercidin sensitizes cells to RIPK1-dependent necroptosis by interfering with NFκB signaling. Cell Death Discovery. In press. https://doi.org/10.1038/s41420-023-01576-x * Corresponding authors. 

 

Chanchal Chauhan, Ana Martinez Del Val, Rainer Niedenthal, Jesper Velgaard Olsen, Alexey Kotlyarov, Simon Bekker-Jensen, Matthias Gaestel*, Manoj B. Menon*. 2023. PRMT5-mediated regulatory arginine methylation of RIPK3. Cell Death Discovery. 9: 14. https://doi.org/10.1038/s41420-023-01299-z *corresponding authors. 

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Annibaldi A, Meier P. (2018). Checkpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer. Trends Mol Med. 24(1):49-65.

 

Dondelinger Y, Vandenabeele P & Bertrand MJM (2016b) Regulation of RIPK1's cell death function by phosphorylation. Cell Cycle 15: 5–6

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Galluzzi L et al. (2018). Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death & Differentiation.  25: 486–541.

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Lalaoui N, Hänggi K, Brumatti G, Chau D, Nguyen N-YN, Vasilikos L, Spilgies L, Heckmann DA, Ma C, Ghisi M, Salmon JM, Matthews G, de-Valle E, Moujalled D, Menon MB, Spall SK, Glaser SP, Richmond J, Lock RB, Condon SM, Gugasyan R, Gaestel M, Guthridge M, Johnstone RW, Munoz L, Wei A, Ekert PG, Vaux DL, Wong W-WL and Silke J.  2016. Targeting p38 or MK2 enhances the anti-leukemic activity of Smac-mimetics. Cancer Cell. 29(2): 145-158.    

 

Menon MB & Gaestel M. 2018. MK2-TNF Signaling comes full-circle. Trends Biochem Sci. 43(3):170-179.

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Menon MB, Gropengießer J, Ruckdeschel K. & Gaestel M. 2017. To die or not to die: Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 function. Mol Cell Oncol. e1396389.

                           

Menon MB*, Gropengießer J*, Fischer J, Novikova L, Deuretzbacher A, Lafera J, Schimmeck H, Czymmeck N, Ronkina N, Kotlyarov A, Aepfelbacher M, Gaestel M & Ruckdeschel K. 2017. p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signaling in inflammation and infection. Nat Cell Biol. 19: 1248–1259. *joint first 

 

Menon MB, Kotlyarov A & Gaestel M. 2011. SB202190-induced cell type-specific vacuole formation & defective autophagy do not depend on p38 MAP kinase inhibition. PLoS One. 6: e23054.

 

Najjar M, Saleh D, Zelic M, Nogusa S, Shah S, Tai A, Finger JN, Polykratis A, Gough PJ, Bertin J, Whalen MJ, Pasparakis M, Balachandran S, Kelliher M, Poltorak A & Degterev A (2016) RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4. Immunity 45: 46–59    

 

Rijal D, Ariana A, Wight A, Kim K, Alturki NA, Aamir Z, Ametepe E, Korneluk RG, Tiedje C, Menon MB, Gaestel M, McComb S, Sad S. 2018. Differentiated macrophages acquire a pro-Inflammatory and cell death-resistant phenotype due to Increasing XIAP and p38-mediated inhibition of RIPK1. J Biol Chem. 293: 11913-27.     

            

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